The Leiden Academic Centre for Drug Research (LACDR) (part of the Faculty of Science of Leiden University) is seeking tenders for the procurement of one advanced microscope capable of performing image-guided single-cell sampling and isolation using confocal imaging and lifetime fluorescence. The microscope will be used for the Exposome Scan Dutch infrastructure and located at the Leiden Cell Observatory (LCO). With this microscope we aim to develop a microscopy-based infrastructure that enables both i) high-throughput phenotypic screening in 3D live advanced cell systems and ii) image-guided single-cell and intracellular component sampling. This infrastructure will serve scientists interested in screening relevant compound libraries in a wide variety of advanced fluorescent reporter cell systems (e.g., human stem cells cultured in 2D and differentiated in 3D microtissues such as liver or kidney organoids) and obtaining a mechanistic understanding of specific imaged phenotypes using a multi-omics approach. The microscope hardware must provide the following functionality: 1) Hardware: Label-free (brightfield or transmission), and lifetime microscopy. Time-lapse microscopy (incubator for a controlled environment). Confocal microscopy for 2D and 3D reporter cell systems cultured in multi-well plates. Automated high-content microscopy (automated stage with high X, Y, Z accuracy for both screening and automated micro sampling). High reproducibility in Z focus needed for time-lapse 2D/3D microscopy (perfect focus/autofocus). 2) Software: Software must be able to communicate with third-party software controlling the micro-sampling robotic. Smart microscopy functionality that allows the automated detection of single-cell events such as: Recognition of intracellular organelles or parts of the cytoplasm. Recognition of a cell next to a target cell. Recognition of cells with different morphologies. Recognition of cells or intracellular components with different lifetime signals. Recognition of specific cell regions based on different fluorescent lifetime signals. Single-cell cloning from cells displaying a unique phenotype. 4) FAIR Compliance: Imaging data must comply with the FAIR principles, including compatibility with the OMERO database and preferentially generating OME-ZARR standards. The microscope must have state-of-the-art reliability and be compatible with Dutch work environment safety regulations (ARBO).
Deadline
De termijn voor de ontvangst van de offertes was 2025-09-04.
De aanbesteding werd gepubliceerd op 2025-07-16.
Aankondiging van een opdracht (2025-07-16) Object Toepassingsgebied van de aanbesteding
Titel: Confocal Microscope
Korte beschrijving:
“The Leiden Academic Centre for Drug Research (LACDR) (part of the Faculty of Science of Leiden University) is seeking tenders for the procurement of one...”
Korte beschrijving
The Leiden Academic Centre for Drug Research (LACDR) (part of the Faculty of Science of Leiden University) is seeking tenders for the procurement of one advanced microscope capable of performing image-guided single-cell sampling and isolation using confocal imaging and lifetime fluorescence. The microscope will be used for the Exposome Scan Dutch infrastructure and located at the Leiden Cell Observatory (LCO).
With this microscope we aim to develop a microscopy-based infrastructure that enables both i) high-throughput phenotypic screening in 3D live advanced cell systems and ii) image-guided single-cell and intracellular component sampling. This infrastructure will serve scientists interested in screening relevant compound libraries in a wide variety of advanced fluorescent reporter cell systems (e.g., human stem cells cultured in 2D and differentiated in 3D microtissues such as liver or kidney organoids) and obtaining a mechanistic understanding of specific imaged phenotypes using a multi-omics approach. The microscope hardware must provide the following functionality:
1) Hardware:
Label-free (brightfield or transmission), and lifetime microscopy.
Time-lapse microscopy (incubator for a controlled environment).
Confocal microscopy for 2D and 3D reporter cell systems cultured in multi-well plates.
Automated high-content microscopy (automated stage with high X, Y, Z accuracy for both screening and automated micro sampling).
High reproducibility in Z focus needed for time-lapse 2D/3D microscopy (perfect focus/autofocus).
2) Software:
Software must be able to communicate with third-party software controlling the micro-sampling robotic.
Smart microscopy functionality that allows the automated detection of single-cell events such as:
Recognition of intracellular organelles or parts of the cytoplasm.
Recognition of a cell next to a target cell.
Recognition of cells with different morphologies.
Recognition of cells or intracellular components with different lifetime signals.
Recognition of specific cell regions based on different fluorescent lifetime signals.
Single-cell cloning from cells displaying a unique phenotype.
4) FAIR Compliance:
Imaging data must comply with the FAIR principles, including compatibility with the OMERO database and preferentially generating OME-ZARR standards.
The microscope must have state-of-the-art reliability and be compatible with Dutch work environment safety regulations (ARBO).
Toon meer
Soort contract: Leveringen
Producten/diensten: Microscopen📦
Geschatte waarde exclusief BTW: 495867.77 EUR 💰
Beschrijving
Beschrijving van de aanbesteding:
“The Leiden Academic Centre for Drug Research (LACDR) (part of the Faculty of Science of Leiden University) is seeking tenders for the procurement of one...”
Beschrijving van de aanbesteding
The Leiden Academic Centre for Drug Research (LACDR) (part of the Faculty of Science of Leiden University) is seeking tenders for the procurement of one advanced microscope capable of performing image-guided single-cell sampling and isolation using confocal imaging and lifetime fluorescence. The microscope will be used for the Exposome Scan Dutch infrastructure and located at the Leiden Cell Observatory (LCO).
With this microscope we aim to develop a microscopy-based infrastructure that enables both i) high-throughput phenotypic screening in 3D live advanced cell systems and ii) image-guided single-cell and intracellular component sampling. This infrastructure will serve scientists interested in screening relevant compound libraries in a wide variety of advanced fluorescent reporter cell systems (e.g., human stem cells cultured in 2D and differentiated in 3D microtissues such as liver or kidney organoids) and obtaining a mechanistic understanding of specific imaged phenotypes using a multi-omics approach. The microscope hardware must provide the following functionality:
1) Hardware:
Label-free (brightfield or transmission), and lifetime microscopy.
Time-lapse microscopy (incubator for a controlled environment).
Confocal microscopy for 2D and 3D reporter cell systems cultured in multi-well plates.
Automated high-content microscopy (automated stage with high X, Y, Z accuracy for both screening and automated micro sampling).
High reproducibility in Z focus needed for time-lapse 2D/3D microscopy (perfect focus/autofocus).
2) Software:
Software must be able to communicate with third-party software controlling the micro-sampling robotic.
Smart microscopy functionality that allows the automated detection of single-cell events such as:
Recognition of intracellular organelles or parts of the cytoplasm.
Recognition of a cell next to a target cell.
Recognition of cells with different morphologies.
Recognition of cells or intracellular components with different lifetime signals.
Recognition of specific cell regions based on different fluorescent lifetime signals.
Single-cell cloning from cells displaying a unique phenotype.
4) FAIR Compliance:
Imaging data must comply with the FAIR principles, including compatibility with the OMERO database and preferentially generating OME-ZARR standards.
The microscope must have state-of-the-art reliability and be compatible with Dutch work environment safety regulations (ARBO).
Toon meer
Aanvullende producten/diensten: Optische microscopen📦
Hoofdlocatie of plaats van uitvoering:
“See documentation”
Plaats van uitvoering: nl363 🏙️
Duur: 12 (MONTH)
Het onderstaande tijdschema is uitgedrukt in aantal maanden.
Gunningscriteria
Kwaliteitscriterium (naam): High-throughput Imaging instruments
Kwaliteitscriterium (weging): 25
Kwaliteitscriterium (naam): Readiness for integration with automated microsampling in multiwell plate
Kwaliteitscriterium (weging): 40
Kwaliteitscriterium (naam): Data Generation and FAIR Data Management
Kwaliteitscriterium (weging): 20
Kwaliteitscriterium (naam): Service and Warranty Requirements
Prijs ✅
Prijs (weging): 160
Titel
Identificatienummer van de partij: LOT-0000
Procedure Soort procedure
Openbare procedure ✅ Administratieve informatie
Termijn voor de ontvangst van inschrijvingen of verzoeken tot deelneming: 2025-09-04 10:00:00 📅
Voorwaarden voor de opening van de offertes: 2025-09-04 10:05:00 📅
Voorwaarden voor de opening van de offertes (plaats): Elektronically
Talen waarin inschrijvingen of aanvragen tot deelneming kunnen worden ingediend: Engels 🗣️
Minimumtermijn gedurende welke de inschrijver de offerte gestand moet doen: 90
Aanvullende informatie Beoordelingsorgaan
Naam: Rechtbank Den Haag
Nationaal registratienummer: 82946175
Postadres: Postbus 20303
Postcode: 2500 EH
Poststad: Den Haag
Regio: nl361 🏙️
Land: Nederland 🇳🇱
E-mail: info@rechtspraak.nl📧
Telefoon: +31883622200📞
URL: https://www.rechtspraak.nl/Organisatie-en-contact/Organisatie/Rechtbanken/Rechtbank-Den-Haag🌏 Herzieningsprocedure
Precieze informatie over de termijn(en) voor herzieningsprocedures:
“Within 20 days after contract-award decision.” Informatie over elektronische workflows
Elektronische facturering wordt aanvaard
Er zal gebruik worden gemaakt van elektronische betaling
Bron: OJS 2025/S 136-470442 (2025-07-16)
Aankondiging van een opdracht (2025-07-18) Object Toepassingsgebied van de aanbesteding
Geschatte waarde exclusief BTW: 495867.77 EUR 💰
Gunningscriteria
Kwaliteitscriterium (naam): Software
Kwaliteitscriterium (weging): 30
Wijzigingen Nieuwe waarde
Tekst:
“Quality criterium added in the publication.” Andere aanvullende informatie
“One quality award criterium wasn't mentioned in the publication. It has been added.”
Bron: OJS 2025/S 137-474892 (2025-07-18)
Aankondiging van een opdracht (2025-07-30) Object Toepassingsgebied van de aanbesteding
Geschatte waarde exclusief BTW: 495867.77 EUR 💰
Wijzigingen Nieuwe waarde
Tekst:
“One item added as award criterium.” Andere aanvullende informatie
“One item added as award criterium.”
Bron: OJS 2025/S 146-504436 (2025-07-30)